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Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs.
- Source :
-
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2016; Vol. 44 (1), pp. 182-7. Date of Electronic Publication: 2014 Jul 03. - Publication Year :
- 2016
-
Abstract
- This study aims to prepare spray-dried inhalable powders containing anti-tubercular drugs-loaded HPMC nanoaggregates for sustained delivery of drugs to the lung. Nanoaggregates were prepared by precipitation technique. Results showed that the powders obtained had excellent aerosolization property. High drug encapsulation efficiency was achieved in HPMC nano aggregates, ranging from 60% to 70%. A single pulmonary dose resulted in therapeutic drug concentrations 40% to 60% in the lungs and in other organs (< 5%) for 24 h. From this study, we can conclude that delivering drugs through pulmonary route is advantageous for local action in lungs.
- Subjects :
- Administration, Inhalation
Animals
Antitubercular Agents chemistry
Antitubercular Agents pharmacology
Drug Liberation
Female
Hypromellose Derivatives chemistry
Isoniazid chemistry
Isoniazid pharmacology
Lung drug effects
Lung metabolism
Male
Nanoparticles ultrastructure
Nasal Sprays
Particle Size
Powders
Rats
Rats, Wistar
Rifampin chemistry
Rifampin pharmacology
Antitubercular Agents pharmacokinetics
Drug Compounding methods
Drug Delivery Systems methods
Isoniazid pharmacokinetics
Nanoparticles chemistry
Rifampin pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 2169-141X
- Volume :
- 44
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Artificial cells, nanomedicine, and biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 24992699
- Full Text :
- https://doi.org/10.3109/21691401.2014.930747