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Long-term cognitive function change among breast cancer survivors.
- Source :
-
Breast cancer research and treatment [Breast Cancer Res Treat] 2014 Aug; Vol. 146 (3), pp. 599-609. Date of Electronic Publication: 2014 Jul 09. - Publication Year :
- 2014
-
Abstract
- Cognitive decline is a common health problem among breast cancer patients and understanding trajectories of cognitive change following among breast cancer survivors is an important public health goal. We conducted a longitudinal study to investigate the cognitive function changes from 18 month to 3 years after breast cancer diagnosis among participants of the Shanghai Breast cancer survivor study, a population-based cohort study of breast cancer survivors. In our study, we completed cognitive function evaluation for 1,300 breast cancer survivors at the 18th month's survey and 1,059 at 36th month's survey, respectively, using a battery of cognitive function measurements. We found the scores in attention and executive function, immediate memory and delayed memory significantly improved from 18 to 36 months after breast cancer diagnosis. The improvements appeared in breast cancer survivors receiving treatments (i.e., surgery, radiotherapy, tamoxifen, or chemotherapy combined with or without tamoxifen), but not in those who received neither chemotherapy nor tamoxifen treatment. The results indicate that cognitive functions, particularly immediate verbal episodic memory, and delayed memory significantly improved among breast cancer survivors from 18 to 36 months after cancer diagnosis. In general, comorbidity was inversely associated with the improvements.
- Subjects :
- Breast Neoplasms complications
Breast Neoplasms therapy
Cognition Disorders etiology
Cognition Disorders pathology
Cognition Disorders therapy
Combined Modality Therapy adverse effects
Drug-Related Side Effects and Adverse Reactions
Female
Humans
Middle Aged
Radiotherapy adverse effects
Breast Neoplasms epidemiology
Cognition Disorders epidemiology
Prognosis
Survivors
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7217
- Volume :
- 146
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Breast cancer research and treatment
- Publication Type :
- Academic Journal
- Accession number :
- 25005574
- Full Text :
- https://doi.org/10.1007/s10549-014-3044-1