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Endoscopic full-thickness resection and laparoscopic surgery for treatment of gastric stromal tumors.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2014 Jul 07; Vol. 20 (25), pp. 8253-9. - Publication Year :
- 2014
-
Abstract
- Aim: To assess the effectiveness of endoscopic full-thickness resection (EFR) and laparoscopic surgery in the treatment of gastric stromal tumors arising from the muscularis propria.<br />Methods: Out of 62 gastric stromal tumors arising from the muscularis propria, each > 1.5 cm in diameter, 32 were removed by EFR, and 30 were removed by laparoscopic surgery. The tumor expression of CD34, CD117, Dog-1, S-100, and SMA was assessed immunohistochemically. The operative time, complete resection rate, length of hospital stay, incidence of complications, and recurrence rate were compared between the two groups. Continuous data were compared using independent samples t-tests, and categorical data were compared using χ (2) tests.<br />Results: The 32 gastric stromal tumors treated by EFR and the 30 treated by laparoscopic surgery showed similar operative time [20-155 min (mean, 78.5 ± 30.1 min) vs 50-120 min (mean, 80.9 ± 46.7 min), P > 0.05], complete resection rate (100% vs 93.3%, P > 0.05), and length of hospital stay [4-10 d (mean, 5.9 ± 1.4 d) vs 4-19 d (mean, 8.9 ± 3.2 d), P >0.05]. None of the patients treated by EFR experienced complications, whereas two patients treated by laparoscopy required a conversion to laparotomy, and one patient had postoperative gastroparesis. No recurrences were observed in either group. Immunohistochemical staining showed that of the 62 gastric stromal tumors diagnosed by gastroscopy and endoscopic ultrasound, six were leiomyomas (SMA-positive), one was a schwannoglioma (S-100 positive), and the remaining 55 were stromal tumors.<br />Conclusion: Some gastric stromal tumors arising from the muscularis propria can be completely removed by EFR. EFR could likely replace surgical or laparoscopic procedures for the removal of gastric stromal tumors.
- Subjects :
- Adult
Aged
Biomarkers, Tumor analysis
Chi-Square Distribution
China
Female
Gastrectomy adverse effects
Gastrointestinal Stromal Tumors chemistry
Gastrointestinal Stromal Tumors pathology
Humans
Immunohistochemistry
Leiomyoma chemistry
Leiomyoma pathology
Length of Stay
Male
Middle Aged
Neoplasm Recurrence, Local
Neurilemmoma chemistry
Neurilemmoma pathology
Operative Time
Postoperative Complications therapy
Retrospective Studies
Stomach Neoplasms chemistry
Stomach Neoplasms pathology
Time Factors
Treatment Outcome
Gastrectomy methods
Gastrointestinal Stromal Tumors surgery
Gastroscopy adverse effects
Laparoscopy adverse effects
Leiomyoma surgery
Neurilemmoma surgery
Stomach Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 20
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25009400
- Full Text :
- https://doi.org/10.3748/wjg.v20.i25.8253