Evaluation of cytomegalovirus infection after six months of liver transplantation in children in shiraz, southern iran.

Authors :: Honar N
Imanieh MH
Dehghani SM
Haghighat M
Geramizadeh B
Yaghobi R
Alborzi A
Ziaeian M
Kazemi K
Nikeghbalian S
Bahador A
Salahi H
Malek Hosseini SA
Source :: International journal of organ transplantation medicine [Int J Organ Transplant Med] 2011; Vol. 2 (1), pp. 20-4.
Publication Year :: 2011
Abstract: Background: Liver transplantation (LT) is a life-saving treatment for end-stage liver diseases (ESLD). Cytomegalovirus (CMV) infection is one of the important causes of morbidity after LT.<br />Objective: To evaluate the incidence of late-onset (after 6 months of LT) CMV infection in pediatric recipients.<br />Methods: A retrospective analysis was conducted to evaluate 50 pediatric patients who underwent LT for 8 years at the LT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We retrospectively investigated episodes of CMV infection after 6 months of LT proven by CMV antigenemia test.<br />Results: Three recipients (6%) developed late-onset CMV infection. These patients finally responded to ganciclovir.<br />Conclusion: CMV infection is one of the most common post-LT viral infections that usually occurs in the first six months of LT. Our study shows that the incidence of late-onset CMV infection is relatively low, but it still remains a significant problem. Therefore, monitoring and management is crucial for improving the survival of children.

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