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The timing of cord clamping and oxidative stress in term newborns.
- Source :
-
Pediatrics [Pediatrics] 2014 Aug; Vol. 134 (2), pp. 257-64. Date of Electronic Publication: 2014 Jul 14. - Publication Year :
- 2014
-
Abstract
- Background: Clamping and cutting of the umbilical cord is the most prevalent of all operations, but the optimal timing of cord clamping is controversial, with different timings offering advantages and disadvantages. This study, for the first time, compares the influence of early and late cord clamping in correlation with oxidative stress and inflammation signaling, Because cord clamping timing may have a significant influence on placenta-to-infant blood transfer, thereby modifying oxygenation of maternal and fetal tissues, and on the transfer of inflammatory mediators throughout the placenta.<br />Methods: Sixty-four pregnant subjects were selected at the Gynecology and Obstetrics Services Department of the Clinico San Cecilio Hospital, Granada, Spain, based on disease-free women who experienced a normal course of pregnancy and a spontaneous, vaginal, single delivery. Half of the subjects had deliveries with early-clamped newborn infants (at 10 s), and the other half had late-clamped deliveries (at 2 min).<br />Results: Erythrocyte catalase activity was significantly greater in the late-clamped group than in the early-clamped group (P < .01 for the umbilical vein and P < .001 for the artery). The values for superoxide dismutase, total antioxidant status, and soluble tumor necrosis factor receptor II were all significantly higher in the late-clamped group compared with the early-clamped group (P < .01, P < .001, and P < .001, respectively).<br />Conclusions: The results suggest a beneficial effect of late cord clamping, produced by an increase in antioxidant capacity and moderation of the inflammatory-mediated effects induced during delivery of term neonates.<br /> (Copyright © 2014 by the American Academy of Pediatrics.)
- Subjects :
- Catalase blood
Constriction, Pathologic
Erythrocytes enzymology
Female
Humans
Inflammation Mediators blood
Interleukin-6 blood
Labor Stage, Third physiology
Ligation standards
Placental Circulation physiology
Postpartum Hemorrhage prevention & control
Pregnancy
Reactive Oxygen Species metabolism
Superoxide Dismutase blood
Term Birth
Time Factors
Tumor Necrosis Factor-alpha blood
Infant, Newborn physiology
Oxidative Stress physiology
Pregnancy Outcome
Umbilical Cord blood supply
Umbilical Cord surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1098-4275
- Volume :
- 134
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 25022744
- Full Text :
- https://doi.org/10.1542/peds.2013-3798