Positive and negative effects of glitazones in carcinogenesis: experimental models vs. clinical practice.

Authors :: Bojková B
Orendáš P
Kubatka P
Péč M
Kassayová M
Kisková T
Kajo K
Source :: Pathology, research and practice [Pathol Res Pract] 2014 Aug; Vol. 210 (8), pp. 465-72. Date of Electronic Publication: 2014 Jun 19.
Publication Year :: 2014
Abstract: Diabetes increases cancer risk, which may be modulated by careful choice of treatment. Experimental reports showed efficacy of glitazones in various in vitro and in vivo models of carcinogenesis, but procarcinogenic effects in some models were reported too, and, similarly, data on cancer incidence in glitazone users are inconsistent. This review summarizes oncostatic effects of glitazones in preclinical and clinical studies and brings a brief summary of their impact on cancer risk in diabetic patients, with a focus on the association between pioglitazone use and bladder cancer.<br /> (Copyright © 2014 Elsevier GmbH. All rights reserved.)

Subjects :: Animals
Diabetes Mellitus, Type 2 complications
Disease Models, Animal
Humans
Hypoglycemic Agents therapeutic use
Neoplasms etiology
Thiazolidinediones therapeutic use
Carcinogenesis drug effects
Diabetes Mellitus, Type 2 drug therapy
Hypoglycemic Agents pharmacology
Neoplasms drug therapy
Thiazolidinediones pharmacology

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