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Antibacterial, antioxidant and hypoglycaemic effects of Thymus capitatus (L.) Hoffmanns. et Link leaves' fractions.
- Source :
-
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2015 Jun; Vol. 30 (3), pp. 360-5. Date of Electronic Publication: 2014 Jul 17. - Publication Year :
- 2015
-
Abstract
- The aim of this study was to examine the bioactivity of the methanol fraction (MF) and n-hexane fraction (HF) of Thymus capitatus leaves in relation to their constituents analysed by gas chromatography and gas chromatography-mass spectrometry. The effects of T. capitatus on the growth of pathogenic bacteria associated with respiratory diseases (13 gram-positive and 4 gram-negative) were determined using a microdilution method. The MF was particularly effective on Streptococcus pneumoniae and Moraxella catarrhalis. The antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid), ferric-reducing antioxidant power and β-carotene bleaching assays. A strong activity using β-carotene bleaching test was observed with the MF (IC50 of 0.7 μg/mL after 30 min of incubation). In the hypoglycaemic test, a selective α-amylase inhibitory activity was detected with the HF begging the most active (IC50 of 422.5 μg/mL). T. capitatus may represent a source of natural bioactive compounds.
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Antioxidants chemistry
Antioxidants isolation & purification
Dose-Response Relationship, Drug
Enzyme Inhibitors chemistry
Enzyme Inhibitors isolation & purification
Enzyme Inhibitors pharmacology
Hyperglycemia enzymology
Hyperglycemia metabolism
Hypoglycemic Agents chemistry
Hypoglycemic Agents isolation & purification
Microbial Sensitivity Tests
Structure-Activity Relationship
alpha-Amylases antagonists & inhibitors
alpha-Amylases metabolism
Anti-Bacterial Agents pharmacology
Antioxidants pharmacology
Bacteria drug effects
Hyperglycemia drug therapy
Hypoglycemic Agents pharmacology
Plant Leaves chemistry
Thymus Plant chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1475-6374
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of enzyme inhibition and medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25032744
- Full Text :
- https://doi.org/10.3109/14756366.2014.930453