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Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Sep 01; Vol. 22 (17), pp. 4955-60. Date of Electronic Publication: 2014 Jun 27. - Publication Year :
- 2014
-
Abstract
- The bioactive metabolite sphingosine-1-phosphate (S1P), a product of sphingosine kinases (SphKs), mediates diverse biological processes such as cell differentiation, proliferation, survival and angiogenesis. A fluorinated analogue of S1P receptor agonist has been synthesized by utilizing a ring opening reaction of oxacycles by a lithiated difluoromethylphosphonate anion as the key reaction. In vitro activity of this S1P analogue is also reported.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Cell Line, Tumor
Cell Proliferation drug effects
Cell Survival drug effects
Dose-Response Relationship, Drug
Halogenation
Humans
Male
Molecular Structure
Organophosphates chemistry
Sphingosine chemical synthesis
Sphingosine chemistry
Sphingosine pharmacology
Sphingosine-1-Phosphate Receptors
Structure-Activity Relationship
Organophosphates chemical synthesis
Organophosphates pharmacology
Receptors, Lysosphingolipid agonists
Sphingosine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 22
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25047939
- Full Text :
- https://doi.org/10.1016/j.bmc.2014.06.038