Back to Search
Start Over
WNT16B from ovarian fibroblasts induces differentiation of regulatory T cells through β-catenin signal in dendritic cells.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2014 Jul 21; Vol. 15 (7), pp. 12928-39. Date of Electronic Publication: 2014 Jul 21. - Publication Year :
- 2014
-
Abstract
- Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in previous studies. In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation. We also demonstrated that fibroblast-derived WNT16B could result in accumulation of β-catenin in dendritic cells and secretion of interleukin-10 (IL-10) and transforming growth factor beta (TGF-β), which contributed to the differentiation of regulatory T cells in a co-culture environment. These results shed light on the roles of WNT16B in immune regulation, especially in regard to cancer treatment.
- Subjects :
- Antigens, Differentiation, T-Lymphocyte genetics
Antigens, Differentiation, T-Lymphocyte metabolism
Cells, Cultured
Female
Humans
Interleukin-10 genetics
Interleukin-10 metabolism
Ovary cytology
T-Lymphocytes, Regulatory cytology
Transforming Growth Factor beta metabolism
Tumor Microenvironment
Wnt Proteins genetics
beta Catenin genetics
Cell Differentiation
Dendritic Cells metabolism
Fibroblasts metabolism
Ovarian Neoplasms metabolism
T-Lymphocytes, Regulatory metabolism
Wnt Proteins metabolism
beta Catenin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25050785
- Full Text :
- https://doi.org/10.3390/ijms150712928