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[Chronic natural killer cell lymphocytosis: eight cases report and literature review].
- Source :
-
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2014 Jul; Vol. 35 (7), pp. 609-13. - Publication Year :
- 2014
-
Abstract
- Objective: To identify the characteristics of chronic natural killer cell lymphocytosis (CNKL).<br />Methods: The clinical data of eight cases defined by the World Health Organization classification was retrospectively analyzed and related literatures were reviewed.<br />Results: Half of the 8 patients were asymptomatic. Among them, the most common abnormalities were leukocytosis with the median of 11.8(4.5-20.0)×10⁹/L and high proportion of lymphocytes [0.78(0.51-0.89)], while anemia and thrombocytopenia only in 1 patient respectively. The absolute CD3⁻CD16⁺ NK cell count with the median of 5.7(2.4-9.6)×10⁹/L increased in peripheral blood. By the end of follow-up, except one case was lost, the other seven patients were in stable condition,including four cases without any medications and three patients receiving chlorambucil or glucocorticoid.<br />Conclusion: As an indolent chronic lymphoproliferative disease, CNKL was presented with mild clinical symptoms and increased number of CD3⁻CD16⁺ NK cells in peripheral blood. Patients with symptoms could be treated with immunosuppressive therapy while those asymptomatic could be followed up without intervention.
Details
- Language :
- Chinese
- ISSN :
- 0253-2727
- Volume :
- 35
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
- Publication Type :
- Academic Journal
- Accession number :
- 25052603
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0253-2727.2014.07.009