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Flavobacterium psychrophilum vaccine development: a difficult task.
- Source :
-
Microbial biotechnology [Microb Biotechnol] 2014 Sep; Vol. 7 (5), pp. 414-23. Date of Electronic Publication: 2014 Jul 23. - Publication Year :
- 2014
-
Abstract
- Bacterial cold water disease (BCWD) is a globally distributed freshwater fish disease caused by the Gram-negative bacterium Flavobacterium psychrophilum. It is a particularly devastating infection in fry salmonids and may lead to high levels of mortality. In spite of its economic impact on fish farms, neither the biology of the bacterium nor the bacterium-host interactions are well understood. This review provides a synopsis of the major problems related to critical remaining questions about research into the use of vaccines against F. psychrophilum and the development of a commercial vaccine against this disease. Studies using sera from convalescent rainbow trout have shown the antigenic properties of different proteins such as OmpH, OmpA and FspA, as well as low and high molecular mass lipopolysaccharide of F. psychrophilum, which are potential candidates for subunit vaccines. Inactivated F. psychrophilum bacterins have been successfully tested as vaccines under laboratory conditions by both immersion and intraperitoneal routes. However, the efficacy and the practical usefulness of these preparations still have to be proved. The use of attenuated and wild-type strains to immunize fish showed that these systems offer high levels of protection. Nevertheless, their application clashes with the regulations for environmental protection in many countries. In conclusion, protective vaccines against BCWD are theoretically possible, but substantial efforts still have to be made in order to permit the development of a commercial vaccine.<br /> (© 2013 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.)
- Subjects :
- Animals
Bacterial Vaccines isolation & purification
Fish Diseases immunology
Fish Diseases microbiology
Fishes
Flavobacteriaceae Infections immunology
Flavobacteriaceae Infections microbiology
Flavobacteriaceae Infections prevention & control
Treatment Outcome
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated immunology
Vaccines, Attenuated isolation & purification
Vaccines, Inactivated administration & dosage
Vaccines, Inactivated immunology
Vaccines, Inactivated isolation & purification
Vaccines, Subunit administration & dosage
Vaccines, Subunit immunology
Vaccines, Subunit isolation & purification
Bacterial Vaccines administration & dosage
Bacterial Vaccines immunology
Fish Diseases prevention & control
Flavobacteriaceae Infections veterinary
Flavobacterium immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1751-7915
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Microbial biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 25056179
- Full Text :
- https://doi.org/10.1111/1751-7915.12099