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Preparation of ibuprofen-loaded chitosan films for oral mucosal drug delivery using supercritical solution impregnation.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2014 Oct 01; Vol. 473 (1-2), pp. 434-41. Date of Electronic Publication: 2014 Jul 28. - Publication Year :
- 2014
-
Abstract
- Drug-loaded chitosan films suitable for oral mucosal drug delivery were prepared using supercritical solution impregnation (SSI) technology. Firstly, chitosan films were obtained via casting method, and the film properties including water-uptake, erosion and mucoadhesive were characterized. SSI process was then employed to load the drug of ibuprofen onto the prepared chitosan films, and the effects of impregnation pressure and temperature on morphologies of the ibuprofen-loaded chitosan films and drug loading capacity (DLC) were studied. The SEM and X-ray diffraction patterns suggested that distinct ibuprofen shapes such as microparticles, flake, rod-like and needle-like occurred after impregnation at different pressures, and DLC varied from 7.9% to 130.4% during the SSI process. The ex vivo release profiles showed that ibuprofen-loaded chitosan films could deliver the drug across the rabbit buccal mucosa, and up to 70% of the ibuprofen was released from the matrix in 460 min. SSI process is a promising method to prepare drug-loaded film formulations for oral mucosal drug delivery, which provides the advantages of low solvent residual and sustained- and controlled- release behavior.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Bacterial Load
Chitosan administration & dosage
Drug Carriers administration & dosage
Drug Compounding methods
Female
Ibuprofen administration & dosage
Mouth Mucosa metabolism
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa growth & development
Rabbits
Solutions
Staphylococcus aureus drug effects
Staphylococcus aureus growth & development
Anti-Inflammatory Agents, Non-Steroidal chemistry
Chitosan chemistry
Drug Carriers chemistry
Ibuprofen chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 473
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 25079432
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2014.07.039