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Giant cell polymyositis associated with myasthenia gravis and thymoma.
- Source :
-
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2014 Dec; Vol. 21 (12), pp. 2252-4. Date of Electronic Publication: 2014 Aug 02. - Publication Year :
- 2014
-
Abstract
- We report a case of a 40-year-old woman who developed generalized muscle weakness over a period of 2 months. Physical examination revealed palpable masses in her arms and hands. Serum creatine kinase levels were elevated. Electromyography showed myopathic changes and 3 Hz repetitive nerve stimulation revealed a decremental pattern on repetitive nerve stimulation. Muscle MRI demonstrated increased signal intensity in the biceps brachii on T1-weighted images. Chest CT scan showed a mediastinal mass suggestive of thymoma. Muscle biopsy revealed giant cell polymyositis. The patient was treated with cholinesterase inhibitors and corticosteroids with improvement of strength, and subsequently underwent thymectomy followed by radiotherapy.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Female
Giant Cells pathology
Giant Cells physiology
Humans
Magnetic Resonance Imaging
Muscle, Skeletal pathology
Muscle, Skeletal physiopathology
Myasthenia Gravis drug therapy
Myasthenia Gravis pathology
Myasthenia Gravis physiopathology
Polymyositis drug therapy
Polymyositis pathology
Polymyositis physiopathology
Thymoma drug therapy
Thymoma pathology
Thymoma physiopathology
Tomography, X-Ray Computed
Myasthenia Gravis complications
Polymyositis complications
Thymoma complications
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2653
- Volume :
- 21
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
- Publication Type :
- Academic Journal
- Accession number :
- 25096712
- Full Text :
- https://doi.org/10.1016/j.jocn.2014.04.027