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Digestive perianastomotic ulcerations and Crohn's disease.
- Source :
-
Journal of Crohn's & colitis [J Crohns Colitis] 2014 Dec; Vol. 8 (12), pp. 1624-31. Date of Electronic Publication: 2014 Aug 06. - Publication Year :
- 2014
-
Abstract
- Background and Aims: Digestive perianastomotic ulcerations (DPAU) have been occasionally reported as late complications of neonatal or childhood surgery.<br />Methods: We report here a series of 14 new cases.<br />Results: Cases were revealed by severe anemia, diarrhea, abdominal pain and growth failure in average 11.5 years after surgery. Ulcerations were most often multiple (n=11), located on the upper part of ileocolonic anastomoses (n=12) and difficult to treat. No granulomas were seen but lymphoid follicles were frequent. In addition, either ASCA or ANCA were positive in 4/9 tested patients and 8/11 genotyped patients exhibited a NOD2 mutation (P<0.0002 when compared to French healthy controls).<br />Conclusion: Altogether, these findings argue for common physiopathological features between DPAU and Crohn's disease and for a prospective follow-up of selected operated children to explore the early events involved in gut inflammatory lesions.<br /> (Copyright © 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Child
Crohn Disease diagnosis
Diagnosis, Differential
Enterocolitis, Necrotizing surgery
Female
Gastroschisis surgery
Heterozygote
Hirschsprung Disease surgery
Humans
Male
Mutation
Nod2 Signaling Adaptor Protein genetics
Time Factors
Young Adult
Anastomosis, Surgical adverse effects
Intestinal Diseases etiology
Postoperative Complications diagnosis
Ulcer etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1876-4479
- Volume :
- 8
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of Crohn's & colitis
- Publication Type :
- Academic Journal
- Accession number :
- 25107846
- Full Text :
- https://doi.org/10.1016/j.crohns.2014.06.011