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Use of greatly-reduced gas flows in flow-modulated comprehensive two-dimensional gas chromatography-mass spectrometry.
- Source :
-
Journal of chromatography. A [J Chromatogr A] 2014 Sep 12; Vol. 1359, pp. 271-6. Date of Electronic Publication: 2014 Jul 25. - Publication Year :
- 2014
-
Abstract
- The present research is specifically based on the use of greatly-reduced gas flows, in flow-modulator (FM) comprehensive two-dimensional gas chromatography systems. In particular, focus of the present research is directed to FM devices characterized by an accumulation stage, and a much briefer re-injection step. It has been widely accepted that the operation of such FM systems requires high gas flows (≥20mL/min), to re-inject the gas-phase contents of sample (or accumulation) loops, onto the second column. On the contrary, it will be herein demonstrated that much lower gas flows (≈ 6-8mL/min) can efficiently perform the modulation step of re-injection. The possibility of using such improved operational conditions is given simply by a fine optimization of the processes of accumulation and re-injection. The application of lower gas flows not only means that second-dimension separations are carried out under better analytical conditions, but, even more importantly, greatly reduces problems which arise when using mass spectrometry (i.e., sensitivity and instrumental pumping capacity).<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-3778
- Volume :
- 1359
- Database :
- MEDLINE
- Journal :
- Journal of chromatography. A
- Publication Type :
- Academic Journal
- Accession number :
- 25108766
- Full Text :
- https://doi.org/10.1016/j.chroma.2014.07.054