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Genetic alterations of chromosome 8 genes in oral cancer.
- Source :
-
Scientific reports [Sci Rep] 2014 Aug 15; Vol. 4, pp. 6073. Date of Electronic Publication: 2014 Aug 15. - Publication Year :
- 2014
-
Abstract
- The clinical relevance of DNA copy number alterations in chromosome 8 were investigated in oral cancers. The copy numbers of 30 selected genes in 33 OSCC patients were detected using the multiplex ligation-dependent probe amplification (MLPA) technique. Amplifications of the EIF3E gene were found in 27.3% of the patients, MYC in 18.2%, RECQL4 in 15.2% and MYBL1 in 12.1% of patients. The most frequent gene losses found were the GATA4 gene (24.2%), FGFR1 gene (24.2%), MSRA (21.2) and CSGALNACT1 (12.1%). The co-amplification of EIF3E and RECQL4 was found in 9% of patients and showed significant association with alcohol drinkers. There was a significant association between the amplification of EIF3E gene with non-betel quid chewers and the negative lymph node status. EIF3E amplifications did not show prognostic significance on survival. Our results suggest that EIF3E may have a role in the carcinogenesis of OSCC in non-betel quid chewers.
- Subjects :
- Chromosome Aberrations
Female
GATA4 Transcription Factor genetics
Humans
Male
Methionine Sulfoxide Reductases genetics
N-Acetylgalactosaminyltransferases genetics
Receptor, Fibroblast Growth Factor, Type 1 genetics
Carcinoma, Squamous Cell genetics
Chromosomes, Human, Pair 8 genetics
DNA Copy Number Variations genetics
Gene Dosage genetics
Mouth Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 4
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 25123227
- Full Text :
- https://doi.org/10.1038/srep06073