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Limitations of beta-lactam therapy for infections caused by susceptible Gram-positive bacteria.
- Source :
-
The Journal of infection [J Infect] 2014 Nov; Vol. 69 Suppl 1, pp. S5-9. Date of Electronic Publication: 2014 Aug 12. - Publication Year :
- 2014
-
Abstract
- Penicillin and related beta-lactam agents have been the most widely used and most important antimicrobials in medical history, and remain the recommended therapy for many infectious diseases 85 years after the discovery of penicillin by Alexander Fleming. Yet the efficacy of these agents has been undermined by two factors - the emergence of clinically significant resistance to the antimicrobial activity of these agents, and clinical situations in which these drugs may be suboptimal (even though the bacterial pathogens are not "resistant" to the drugs). Observations in experimental infection models in animals (group A streptococcal myositis, pneumococcal meningitis and pneumonia, group B streptococcal sepsis) and in some cases clinical studies suggest that monotherapy with beta-lactam antibiotics may be inferior to treatment with other types of antibiotics, alone or in combination with beta-lactams - even in situations where the bacterial pathogens remain fully "susceptible" to beta-lactams in vitro.<br /> (Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Anti-Bacterial Agents pharmacology
Gram-Positive Bacteria classification
Gram-Positive Bacterial Infections diagnosis
Humans
Mice
Severity of Illness Index
Treatment Outcome
beta-Lactams pharmacology
Anti-Bacterial Agents therapeutic use
Gram-Positive Bacteria drug effects
Gram-Positive Bacterial Infections drug therapy
Gram-Positive Bacterial Infections microbiology
beta-Lactams therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2742
- Volume :
- 69 Suppl 1
- Database :
- MEDLINE
- Journal :
- The Journal of infection
- Publication Type :
- Academic Journal
- Accession number :
- 25124369
- Full Text :
- https://doi.org/10.1016/j.jinf.2014.07.010