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Inverse associations of total and decaffeinated coffee with liver enzyme levels in National Health and Nutrition Examination Survey 1999-2010.
- Source :
-
Hepatology (Baltimore, Md.) [Hepatology] 2014 Dec; Vol. 60 (6), pp. 2091-8. Date of Electronic Publication: 2014 Oct 30. - Publication Year :
- 2014
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Abstract
- Unlabelled: Coffee may have hepatoprotective effects and higher coffee consumption has been associated inversely with levels of liver enzymatic markers. However, it is unclear whether decaffeinated coffee is also associated with liver enzymes. The study population included 27,793 participants, age 20 or older, in the U.S. National Health and Nutrition Examination Survey (1999-2010). Coffee intake was evaluated by 24-hour dietary recall. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transaminase (GGT) were measured. We examined the relationship between coffee intake and enzymatic levels using weighted multiple variable logistic (abnormally elevated levels of enzymes) and linear regression (continuous enzymatic levels). Total coffee consumption was inversely associated with abnormal levels of all four liver enzymes and continuous levels of AST, ALP, and GGT. Compared to those reporting no coffee consumption, participants reporting ≥ 3 cups per day had an odds ratio (OR; 95% confidence interval [CI]) of 0.75 (0.63, 0.89), 0.82 (0.68, 0.98), 0.73 (0.55, 0.95), and 0.69 (0.57, 0.83) for abnormal levels of ALT, AST, ALP, and GGT, respectively. Similar inverse associations were found with decaffeinated coffee intake and abnormal levels of ALT (OR (≥ 2 vs 0 cup/d): 0.62 [0.41, 0.94]), AST (0.74 [0.49, 1.11]), and GGT (0.70 [0.49-1.00]).<br />Conclusion: Higher intakes of coffee, regardless of its caffeine content, were associated with lower levels of liver enzymes.<br /> (Published 2014. This article is a U.S. Government work and is in the public domain in the USA.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Alanine Transaminase blood
Alkaline Phosphatase blood
Aspartate Aminotransferases blood
Cross-Sectional Studies
Female
Humans
Liver drug effects
Male
Middle Aged
Nutrition Surveys
Young Adult
gamma-Glutamyltransferase blood
Biomarkers blood
Caffeine pharmacology
Coffee
Liver enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3350
- Volume :
- 60
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Hepatology (Baltimore, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 25124935
- Full Text :
- https://doi.org/10.1002/hep.27367