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TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
- Source :
-
Developmental cell [Dev Cell] 2014 Aug 25; Vol. 30 (4), pp. 394-409. Date of Electronic Publication: 2014 Aug 07. - Publication Year :
- 2014
-
Abstract
- Autophagy, a homeostatic process whereby eukaryotic cells target cytoplasmic cargo for degradation, plays a broad role in health and disease states. Here we screened the TRIM family for roles in autophagy and found that half of TRIMs modulated autophagy. In mechanistic studies, we show that TRIMs associate with autophagy factors and act as platforms assembling ULK1 and Beclin 1 in their activated states. Furthermore, TRIM5α acts as a selective autophagy receptor. Based on direct sequence-specific recognition, TRIM5α delivered its cognate cytosolic target, a viral capsid protein, for autophagic degradation. Thus, our study establishes that TRIMs can function both as regulators of autophagy and as autophagic cargo receptors, and reveals a basis for selective autophagy in mammalian cells.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Antiviral Restriction Factors
Apoptosis Regulatory Proteins metabolism
Autophagy-Related Protein-1 Homolog
Beclin-1
Binding Sites
Carrier Proteins chemistry
HeLa Cells
Humans
Intracellular Signaling Peptides and Proteins metabolism
Membrane Proteins metabolism
Protein Binding
Protein Serine-Threonine Kinases metabolism
Tripartite Motif Proteins
Ubiquitin-Protein Ligases
Autophagy
Carrier Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1551
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Developmental cell
- Publication Type :
- Academic Journal
- Accession number :
- 25127057
- Full Text :
- https://doi.org/10.1016/j.devcel.2014.06.013