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Predonation screening of candidate donors and prevention of window period donations.
- Source :
-
Transfusion [Transfusion] 2015 Feb; Vol. 55 (2), pp. 373-8. Date of Electronic Publication: 2014 Aug 07. - Publication Year :
- 2015
-
Abstract
- Background: Infectious window period donations slip through routine donor screening procedures. To explore the potential value of predonation screening of candidate donors, we compared the proportion of incident transfusion-transmissible infections in candidate donors, in first-time donors, and in repeat donors.<br />Study Design and Methods: A retrospective analysis was performed of all incident hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections in candidate, first-time, and repeat donors in the Netherlands during the period 2009 to 2013.<br />Results: In total, 176,716 candidate donors, 144,226 first-time donations, and 4,143,455 repeat donations were screened for HBV, HCV, and HIV infection. Acute HBV infection was identified in the predonation sample of six candidate donors. One first-time donor, testing HIV-negative at predonation screening, tested positive for anti-HIV and HIV RNA in the first donation 29 days later. Among repeat donations we identified 15, one, and six incident HBV, HCV and HIV infections, respectively. The proportion of incident infections among candidate donors/first-time donations/repeat donations was for HBV, 3.40/0/0.36; for HCV, 0/0/0.02; and for HIV 0/0.69/0.14 per 100,000, respectively.<br />Conclusion: Predonation screening of candidate donors very likely causes a loss of donations, but it might prevent undetected window period donations. Further studies are necessary to determine the value of predonation screening as an additional safety measure.<br /> (© 2014 AABB.)
- Subjects :
- Adult
Female
HIV-1
Hepacivirus
Hepatitis B virus
Humans
Incidence
Male
Retrospective Studies
Time Factors
Blood Donors
Donor Selection methods
HIV Infections blood
HIV Infections epidemiology
HIV Infections prevention & control
HIV Infections transmission
Hepatitis B blood
Hepatitis B epidemiology
Hepatitis B prevention & control
Hepatitis B transmission
Hepatitis C blood
Hepatitis C epidemiology
Hepatitis C prevention & control
Hepatitis C transmission
Subjects
Details
- Language :
- English
- ISSN :
- 1537-2995
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Transfusion
- Publication Type :
- Academic Journal
- Accession number :
- 25130605
- Full Text :
- https://doi.org/10.1111/trf.12809