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Nepafenac 0.1% plus dexamethasone 0.1% versus dexamethasone alone: effect on macular swelling after cataract surgery.
- Source :
-
Journal of cataract and refractive surgery [J Cataract Refract Surg] 2014 Sep; Vol. 40 (9), pp. 1498-505. - Publication Year :
- 2014
-
Abstract
- Purpose: To evaluate the efficacy of adding nepafenac 0.1% ophthalmic suspension to dexamethasone 0.1% eyedrops in controlling macular swelling and other manifestations of inflammation after uneventful cataract surgery.<br />Setting: Ophthalmology Department, Mölndal Hospital, Gothenburg, and St. Erik Eye Hospital, Stockholm, Sweden.<br />Design: Randomized double-masked clinical trial.<br />Methods: Patients at low risk for postoperative inflammation were recruited and randomized to the nepafenac group or to the control group. Postoperative swelling of the macula was assessed with ocular coherence tomography. Laser flare intensity, corrected distance visual acuity, ocular discomfort, and visual complaints were also recorded.<br />Results: The analysis of intent-to-treat population comprised 75 patients in the nepafenac group and 77 patients in the control group. Compared with the control regimen, add-on nepafenac resulted in statistically significant reductions in the following parameters: change in macular volume at 3 weeks and 6 weeks (P<.001), proportion of patients with more than 10 μm of swelling in the central macula at 3 weeks (P<.0001) and 6 weeks (P=.02), mean laser flare intensity at 1 day (P=.029), pain during the first 24 hours postoperatively (P<.0001), and ocular discomfort and photophobia during the first 3 postoperative weeks (P=.0058 and P=.0052, respectively).<br />Conclusion: The combination of topical nepafenac and steroid treatment reduced subclinical macular swelling and inflammation as well as subjective complaints, indicating it is an efficient antiinflammatory regimen after cataract surgery.<br />Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.<br /> (Copyright © 2014 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Administration, Topical
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Benzeneacetamides administration & dosage
Dexamethasone administration & dosage
Double-Blind Method
Drug Therapy, Combination
Female
Glucocorticoids administration & dosage
Humans
Lens Implantation, Intraocular
Macular Edema etiology
Male
Middle Aged
Ophthalmic Solutions
Phenylacetates administration & dosage
Prospective Studies
Uveitis, Anterior drug therapy
Visual Acuity drug effects
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Benzeneacetamides therapeutic use
Dexamethasone therapeutic use
Glucocorticoids therapeutic use
Macular Edema drug therapy
Phacoemulsification
Phenylacetates therapeutic use
Postoperative Complications
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4502
- Volume :
- 40
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of cataract and refractive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 25135542
- Full Text :
- https://doi.org/10.1016/j.jcrs.2013.12.023