Paracrine network: another step in the complexity of resistance to EGFR blockade?

Authors :: Salazar R
Capellà G
Tabernero J
Source :: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2014 Dec 15; Vol. 20 (24), pp. 6227-9. Date of Electronic Publication: 2014 Aug 19.
Publication Year :: 2014
Abstract: Increased secretion of EGFR ligands amphiregulin and TGFα by limited KRAS-mutant clones is suggested as a paracrine resistance mechanism to anti-EGFR antibodies in colorectal cancer models. These findings are biologically sound but need to be replicated, including in the clinical setting, to foresee whether they are clinically relevant and therapeutically exploitable.<br /> (©2014 American Association for Cancer Research.)

Subjects :: Humans
Amphiregulin metabolism
Colorectal Neoplasms metabolism
Drug Resistance, Neoplasm
ErbB Receptors antagonists & inhibitors
Paracrine Communication
Transforming Growth Factor alpha metabolism

Language :: English
ISSN :: 1557-3265
Volume :: 20
Issue :: 24
Database :: MEDLINE
Journal :: Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Type :: Academic Journal
Accession number :: 25139340
Full Text :: https://doi.org/10.1158/1078-0432.CCR-14-1615

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