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Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders.
- Source :
-
ELife [Elife] 2014 Aug 19; Vol. 3, pp. e02917. Date of Electronic Publication: 2014 Aug 19. - Publication Year :
- 2014
-
Abstract
- Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34-1.44) and 2.19 (95% CI 2.15-2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the corresponding risks were 1.46 (95% CI 1.36-1.58) and 2.70 (95% CI 2.59-2.81), respectively. Our study calls for extra surveillance for children with a family history of AUDs, and further studies examining the underlying mechanisms are needed.<br /> (Copyright © 2014, Sundquist et al.)
- Subjects :
- Adolescent
Adult
Alcoholism complications
Alcoholism physiopathology
Attention Deficit Disorder with Hyperactivity etiology
Attention Deficit Disorder with Hyperactivity physiopathology
Autistic Disorder etiology
Autistic Disorder physiopathology
Child
Confidence Intervals
Epidemiological Monitoring
Female
Humans
Incidence
Longitudinal Studies
Male
Parents
Risk Factors
Sweden epidemiology
Alcoholism epidemiology
Attention Deficit Disorder with Hyperactivity epidemiology
Autistic Disorder epidemiology
Registries
Subjects
Details
- Language :
- English
- ISSN :
- 2050-084X
- Volume :
- 3
- Database :
- MEDLINE
- Journal :
- ELife
- Publication Type :
- Academic Journal
- Accession number :
- 25139954
- Full Text :
- https://doi.org/10.7554/eLife.02917