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Effects of glutamine alone on the acute necrotizing pancreatitis in rats.
- Source :
-
The Journal of surgical research [J Surg Res] 2015 Jan; Vol. 193 (1), pp. 161-7. Date of Electronic Publication: 2014 Jul 19. - Publication Year :
- 2015
-
Abstract
- Background: The effects of the glutamine on the acute pancreatitis are controversial in the clinical and experimental studies. The aim of this study was to investigate the influence of glutamine alone on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats.<br />Material and Methods: Fifty-two male Sprague-Dawley rats weighing 300-350 g were used. Rats were divided into four groups as sham + saline, sham + glutamine, ANP + saline and ANP + glutamine. ANP in rats was induced by glycodeoxycholic acid. The extent of acinar cell injury, mortality, systemic cardiorespiratory variables, functional capillary density, renal/hepatic functions, and changes in some enzyme markers for pancreatic and lung tissue were investigated during ANP in rats.<br />Results: The induction of ANP resulted in a significant increase in the mortality rate, pancreatic necrosis, and serum activity of amylase, alanine aminotransferase, interleukin-6, lactate dehydrogenase in bronchoalveolar lavage fluid, serum concentration of urea, and tissue activity of myeloperoxidase and malondialdehyde in the pancreas and lung, and a significant decrease in concentrations of calcium, blood pressure, urine output, pO2, and functional capillary density. The use of glutamine alone improved these changes.<br />Conclusions: Glutamine demonstrated beneficial effect on the course of ANP in rats. Therefore, it may be used by itself in the treatment of acute pancreatitis.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Alanine Transaminase blood
Amylases blood
Animals
Detergents toxicity
Disease Models, Animal
Interleukin-6 blood
L-Lactate Dehydrogenase blood
Male
Pancreas blood supply
Pancreas drug effects
Pancreatitis, Acute Necrotizing mortality
Rats, Sprague-Dawley
Sodium Chloride pharmacology
Treatment Outcome
Glutamine pharmacology
Glycodeoxycholic Acid toxicity
Microcirculation drug effects
Pancreatitis, Acute Necrotizing chemically induced
Pancreatitis, Acute Necrotizing drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1095-8673
- Volume :
- 193
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of surgical research
- Publication Type :
- Academic Journal
- Accession number :
- 25145902
- Full Text :
- https://doi.org/10.1016/j.jss.2014.07.029