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Mimiviridae, Marseilleviridae, and virophages as emerging human pathogens causing healthcare-associated infections.
- Source :
-
GMS hygiene and infection control [GMS Hyg Infect Control] 2014 Aug 19; Vol. 9 (2), pp. Doc16. Date of Electronic Publication: 2014 Aug 19 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Aim: During the last decade it became obvious that viruses belonging to Mimiviridae and Marseilleviridae families (order Megavirales), may be potential causative agents of pneumonia. Thus, we have performed a review of the association of Mimiviridae, Marseilleviridae, and virophages with pneumonia, particularly healthcare-associated pneumonia, and other infections of the respiratory tract.<br />Results and Discussion: According to the analysis of the published articles, viruses belonging to Mimiviridae family can be potential agents of both community-acquired and healthcare-associated pneumonia. In particular, these viruses may be associated with poor outcome in patients of intensive care units. The exact mechanism of their pathogenicity, however, still remains unclear. The discrepancies between the results obtained by serological and genomic methods could be explained by the high polymorphism of nucleotide sequences of Mimiviridae family representatives. Further investigations on the Mimiviridae pathogenicity and on the determination of Mimiviridae-caused pneumonia risk groups are required. However, the pathogenicity of the viruses belonging to Marseilleviridae family and virophages is unclear up to now.
Details
- Language :
- English
- ISSN :
- 2196-5226
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- GMS hygiene and infection control
- Publication Type :
- Academic Journal
- Accession number :
- 25152861
- Full Text :
- https://doi.org/10.3205/dgkh000236