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Brucella abortus DNA is a major bacterial agonist to activate the host innate immune system.
- Source :
-
Microbes and infection [Microbes Infect] 2014 Dec; Vol. 16 (12), pp. 979-84. Date of Electronic Publication: 2014 Aug 27. - Publication Year :
- 2014
-
Abstract
- Immunity against Brucella abortus depends on the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Signaling pathways triggered by Brucella DNA involves TLR9, AIM2 and possibly STING and MAVS. Herein, we review the advances in B. abortus DNA sensing by host innate immune receptors and the progress in this field.<br /> (Copyright © 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Animals
Brucella abortus genetics
Brucellosis genetics
Brucellosis immunology
Brucellosis metabolism
Cytosol metabolism
DNA, Bacterial genetics
Endosomes metabolism
Host-Pathogen Interactions genetics
Humans
Signal Transduction
Toll-Like Receptor 9 genetics
Toll-Like Receptor 9 metabolism
Brucella abortus immunology
DNA, Bacterial immunology
Host-Pathogen Interactions immunology
Immunity, Innate physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1769-714X
- Volume :
- 16
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Microbes and infection
- Publication Type :
- Academic Journal
- Accession number :
- 25173577
- Full Text :
- https://doi.org/10.1016/j.micinf.2014.08.010