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Medical history, lifestyle, and occupational risk factors for hairy cell leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
- Source :
-
Journal of the National Cancer Institute. Monographs [J Natl Cancer Inst Monogr] 2014 Aug; Vol. 2014 (48), pp. 115-24. - Publication Year :
- 2014
-
Abstract
- Background: Little is known about the etiology of hairy cell leukemia (HCL), a rare B-cell lymphoproliferative disorder with marked male predominance. Our aim was to identify key risk factors for HCL.<br />Methods: A pooled analysis of individual-level data for 154 histologically confirmed HCL cases and 8834 controls from five case-control studies, conducted in Europe and Australia, was undertaken. Age-, race and/or ethnicity-, sex-, and study-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression.<br />Results: The usual patterns for age and sex in HCL were observed, with a median age of 55 years and sex ratio of 3.7 males to females. Cigarette smoking was inversely associated with HCL (OR = 0.51, 95% CI = 0.37 to 0.71) with dose-response relationships observed for duration, frequency, and lifetime cigarette smoking (P(trend) < .001). In contrast, occupation as a farmer was positively associated with HCL (OR = 2.34, 95% CI = 1.36 to 4.01), with a dose-response relationship observed for duration (OR = 1.82, 95% CI = 0.85 to 3.88 for ≤ 10 years vs never; and OR = 2.98, 95% CI = 1.50 to 5.93 for >10 years vs never; P(trend) = .025). Adult height was also positively associated with HCL (OR = 2.69, 95% CI = 1.39 to 5.29 for upper vs lower quartile of height). The observed associations remained consistent in multivariate analysis.<br />Conclusions: Our observations of an increased risk of HCL from farming exposures and decreased risk from smoking exposures, independent of one another, support a multifactorial origin and an etiological specificity of HCL compared with other non-Hodgkin lymphoma subtypes. The positive association with height is a novel finding that needs replication.<br /> (Published by Oxford University Press 2014.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Australia epidemiology
Australia ethnology
Case-Control Studies
Comorbidity
Europe epidemiology
Europe ethnology
Female
Humans
Male
Middle Aged
North America epidemiology
North America ethnology
Odds Ratio
Risk Factors
Sex Factors
Young Adult
Leukemia, Hairy Cell epidemiology
Leukemia, Hairy Cell etiology
Life Style
Occupational Exposure
Subjects
Details
- Language :
- English
- ISSN :
- 1745-6614
- Volume :
- 2014
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- Journal of the National Cancer Institute. Monographs
- Publication Type :
- Academic Journal
- Accession number :
- 25174032
- Full Text :
- https://doi.org/10.1093/jncimonographs/lgu004