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Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD.
- Source :
-
European journal of radiology [Eur J Radiol] 2014 Nov; Vol. 83 (11), pp. 2093-101. Date of Electronic Publication: 2014 Aug 17. - Publication Year :
- 2014
-
Abstract
- Objectives: Oxygen-enhanced MRI (OE-MRI) biomarkers have potential value in assessment of COPD, but need further evaluation before treatment-induced changes can be interpreted. The objective was to evaluate how OE-MRI parameters of regional ventilation and oxygen uptake respond to standard pharmacological interventions in COPD, and how the response compares to that of gold standard pulmonary function tests.<br />Materials and Methods: COPD patients (n=40), mean FEV1 58% predicted normal, received single-dose inhaled formoterol 9μg, or placebo, followed by 8 weeks treatment bid with a combination of budesonide and formoterol Turbuhaler(®) 320/9μg or formoterol Turbuhaler(®). OE-MRI biomarkers were obtained, as well as X-ray computed tomography (CT) biomarkers and pulmonary function tests, in a two-center study. An ANCOVA statistical model was used to assess effect size of intervention measurable in OE-MRI parameters of lung function.<br />Results: OE-MRI data were successfully acquired at both study sites. 8-week treatment with budesonide/formoterol significantly decreased lung wash-out time by 31% (p<0.01), decreased the change in lung oxygen level upon breathing pure oxygen by 13% (p<0.05) and increased oxygen extraction from the lung by 58% (p<0.01). Single-dose formoterol increased both lung wash-out time (+47%, p<0.05) and lung oxygenation time (+47%, p<0.05). FEV1 was improved by single-dose formoterol (+12%, p<0.001) and 8 weeks of budesonide/formoterol (+ 18%, p<0.001), consistent with published studies.<br />Conclusions: In COPD, OE-MRI parameters showed response to both single-dose bronchodilatory effects of a β2-agonist, formoterol, and 8-week treatment with an inhaled corticosteroid, budesonide, and the measurements are feasible in a small-scale multi-center trial setting.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adrenal Cortex Hormones administration & dosage
Bronchodilator Agents administration & dosage
Budesonide administration & dosage
Drug Combinations
Feasibility Studies
Female
Forced Expiratory Volume drug effects
Formoterol Fumarate administration & dosage
Humans
Male
Middle Aged
Oxygen
Pulmonary Disease, Chronic Obstructive drug therapy
Pulmonary Disease, Chronic Obstructive physiopathology
Respiratory Function Tests
Adrenal Cortex Hormones pharmacokinetics
Bronchodilator Agents pharmacokinetics
Budesonide pharmacokinetics
Formoterol Fumarate pharmacokinetics
Magnetic Resonance Imaging
Pulmonary Disease, Chronic Obstructive pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7727
- Volume :
- 83
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European journal of radiology
- Publication Type :
- Academic Journal
- Accession number :
- 25176287
- Full Text :
- https://doi.org/10.1016/j.ejrad.2014.08.004