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[Therapy-related chronic myelogenous leukemia following RFM therapy in a patient with follicular lymphoma].
- Source :
-
[Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2014 Aug; Vol. 55 (8), pp. 970-4. - Publication Year :
- 2014
-
Abstract
- Therapy-related myelodysplastic syndrome and acute myelogenous leukemia are increasingly being recognized as treatment complications in patients receiving chemotherapy or radiotherapy for previous neoplasms. However, therapy-related chronic myelogenous leukemia is relatively rare. A 61-year-old woman with a history of radiation therapy for breast cancer had previously, in 2007, received 4 courses of chemotherapy (RFM: rituximab, fludarabine, and mitoxantrone) for follicular lymphoma. In 2010, she was diagnosed with chronic-phase chronic myelogenous leukemia (CML) with Philadelphia chromosome but no other cytogenetic anomalies. Although a complete cytogenetic response (CCyR) was achieved with imatinib therapy, she developed leukocytosis with lymphoblasts and lymphoid crisis was diagnosed in January 2013. G-banded karyotyping showed 45, XX, -7, t, (9;22)(q33;q11.2). Unrelated bone marrow stem cell transplantation was performed after she had achieved a CCyR with dasatinib therapy. Polymerase chain reaction detected no major bcr/abl transcript in her bone marrow 42 days after transplantation. The majority of secondary leukemias resulting from the use of cytotoxic drugs can be divided into two well-defined groups depending on whether the patient has received alkylating agents or topoisomerase II inhibitors. However, concerns regarding the leukemogenic potential of fludarabine-based chemotherapy are growing. The potential risk of therapy-related leukemias including CML needs to be considered following fludarabine-based chemotherapy.
- Subjects :
- Antibodies, Monoclonal, Murine-Derived administration & dosage
Antibodies, Monoclonal, Murine-Derived adverse effects
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Female
Humans
Lymphoma, Follicular complications
Lymphoma, Follicular diagnosis
Middle Aged
Mitoxantrone administration & dosage
Mitoxantrone adverse effects
Rituximab
Vidarabine administration & dosage
Vidarabine adverse effects
Vidarabine analogs & derivatives
Antineoplastic Combined Chemotherapy Protocols adverse effects
Leukemia, Myelogenous, Chronic, BCR-ABL Positive chemically induced
Lymphoma, Follicular drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0485-1439
- Volume :
- 55
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- [Rinsho ketsueki] The Japanese journal of clinical hematology
- Publication Type :
- Academic Journal
- Accession number :
- 25186488