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An ultrasensitive label-free electrochemical biosensor for microRNA-21 detection based on a 2'-O-methyl modified DNAzyme and duplex-specific nuclease assisted target recycling.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2014 Oct 21; Vol. 50 (82), pp. 12375-7. - Publication Year :
- 2014
-
Abstract
- Based on a highly efficient 2'-O-methyl modified G-quadruplex-hemin DNAzyme and duplex-specific nuclease (DSN) assisted target recycling, a novel label-free electrochemical biosensor for microRNA-21 (miR-21) detection is developed here. By employing the strategy, this DNA biosensor can detect as low as 8 aM miR-21 and exhibits high discrimination ability even against a single-base mismatch.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 50
- Issue :
- 82
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 25187259
- Full Text :
- https://doi.org/10.1039/c4cc05541a