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Combining radiation and immunotherapy: a new systemic therapy for solid tumors?
- Source :
-
Cancer immunology research [Cancer Immunol Res] 2014 Sep; Vol. 2 (9), pp. 831-8. - Publication Year :
- 2014
-
Abstract
- With the recent success of checkpoint inhibitors and other immunomodulating agents, there has been renewed interest in the combination of such agents with radiation. The biologic premise behind such a strategy is that the tumor-antigen release achieved by localized radiation will promote specific tumor targeting by the adaptive immune system, which can be augmented further by systemic immune-stimulating agents. In this manner, clinicians hope to induce a phenomenon known as the abscopal effect, whereby localized radiation results in immune-mediated tumor regression in disease sites well outside of the radiation field. Herein, we present a comprehensive overview of the early clinical and preclinical evidence behind this approach.<br /> (©2014 American Association for Cancer Research.)
Details
- Language :
- English
- ISSN :
- 2326-6074
- Volume :
- 2
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cancer immunology research
- Publication Type :
- Academic Journal
- Accession number :
- 25187273
- Full Text :
- https://doi.org/10.1158/2326-6066.CIR-14-0069