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Chromosome boundary elements and regulation of heterochromatin spreading.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2014 Dec; Vol. 71 (24), pp. 4841-52. Date of Electronic Publication: 2014 Sep 07. - Publication Year :
- 2014
-
Abstract
- Chromatin is generally classified as euchromatin or heterochromatin, each with distinct histone modifications, compaction levels, and gene expression patterns. Although the proper formation of heterochromatin is essential for maintaining genome integrity and regulating gene expression, heterochromatin can also spread into neighboring regions in a sequence-independent manner, leading to the inactivation of genes. Because the distance of heterochromatin spreading is stochastic, the formation of boundaries, which block the spreading of heterochromatin, is critical for maintaining stable gene expression patterns. Here we review the current understanding of the mechanisms underlying heterochromatin spreading and boundary formation.
Details
- Language :
- English
- ISSN :
- 1420-9071
- Volume :
- 71
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 25192661
- Full Text :
- https://doi.org/10.1007/s00018-014-1725-x