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Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2015 Mar; Vol. 54 (3), pp. 449-57. Date of Electronic Publication: 2014 Sep 05. - Publication Year :
- 2015
-
Abstract
- Objective: The aim of this study was to determine whether anti-nucleosome antibodies function as activity-specific biomarkers in SLE.<br />Methods: Fifty-one patients were recruited and followed prospectively with periodic clinical and biochemical assessments over a 14-month period. Disease activity was determined by the SLEDAI-2K. Anti-nucleosome antibody levels were measured by an ELISA and its utility as an activity-specific biomarker as compared with that of anti-dsDNA antibodies and C3 was assessed both at baseline and in longitudinal analysis.<br />Results: Anti-nucleosome antibodies were significantly elevated in SLE patients vs controls and showed a moderate positive correlation with disease activity. The utility of anti-nucleosome antibodies in identifying patients with active disease in a cross-sectional analysis was comparable to that of anti-dsDNA antibodies and C3. Analysis of variance demonstrated that the level of anti-nucleosome antibodies and C3 varied significantly with changes in disease activity over time. Changes in clinical state were not mirrored by changes in anti-dsDNA antibodies. In time-dependent analysis, anti-nucleosome antibodies showed a better fit over time than anti-dsDNA antibodies and C3. In pairwise comparisons, C3 and anti-nucleosome antibodies outperformed other models, including the conventional pairing of C3 and anti-dsDNA antibodies, however, no biomarker alone or as a group accurately predicted impending remissions or exacerbations.<br />Conclusion: Anti-nucleosome antibodies demonstrate greater fidelity as a biomarker for changes in SLE disease activity than traditional biomarkers, supporting the routine monitoring of this antibody in clinical practice.<br /> (© The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Adolescent
Adult
Aged
Biomarkers blood
Complement C3 metabolism
Cross-Sectional Studies
DNA immunology
Female
Humans
Longitudinal Studies
Male
Middle Aged
Prospective Studies
Sensitivity and Specificity
Time Factors
Young Adult
Antibodies, Anti-Idiotypic blood
Lupus Erythematosus, Systemic blood
Lupus Erythematosus, Systemic diagnosis
Nucleosomes immunology
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 54
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 25193804
- Full Text :
- https://doi.org/10.1093/rheumatology/keu326