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Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.
- Source :
-
Nature genetics [Nat Genet] 2014 Oct; Vol. 46 (10), pp. 1110-4. Date of Electronic Publication: 2014 Sep 07. - Publication Year :
- 2014
-
Abstract
- To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 × 10(-5)) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595) and 12q24 (rs10492336). The minor alleles of each of these loci showed protective effects, with odds ratios (95% confidence intervals) of 0.73 (0.68-0.78; P = 1.00 × 10(-20)), 0.78 (0.72-0.84; P = 2.43 × 10(-15)) and 0.71 (0.65-0.77; P = 4.48 × 10(-14)), respectively. None of these variants showed an interaction with smoking or drinking. This is the first GWAS to our knowledge solely on LSCC, and the findings might advance understanding of the etiology of LSCC.
- Subjects :
- Aged
Asian People genetics
Carcinoma, Squamous Cell ethnology
China
Chromosomes, Human, Pair 11 genetics
Chromosomes, Human, Pair 12 genetics
Chromosomes, Human, Pair 6 genetics
Esophageal Neoplasms ethnology
Female
Gene Frequency
Genetic Predisposition to Disease etiology
Genotype
Humans
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Carcinoma, Squamous Cell genetics
Esophageal Neoplasms genetics
Genetic Loci genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 46
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 25194280
- Full Text :
- https://doi.org/10.1038/ng.3090