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Decreased intratumoral Foxp3 Tregs and increased dendritic cell density by neoadjuvant chemotherapy associated with favorable prognosis in advanced gastric cancer.
- Source :
-
International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2014 Jul 15; Vol. 7 (8), pp. 4685-94. Date of Electronic Publication: 2014 Jul 15 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Although neoadjuvant chemotherapy (NACT) has been increasingly used to improve the outcome of advanced gastric cancer (GC) for decades, its precise efficacy has been difficult to evaluate yet. Abundant studies have investigated the predictive factors that represent the effect of NACT on advanced GC. In the present study, the intratumoral infiltration of regulatory T cells (Tregs) and dendritic cells (DCs) response to NACT in advanced GC and their correlation with prognosis were evaluated. Infiltration of Tregs (marked by Foxp3) and DCs (marked by S-100) in 102 advanced GC specimens with or without NACT was measured using immunohistochemical method. Intratumoral infiltration of Foxp3 Tregs was significantly lower and DC density was significantly higher in NACT group than that in nNACT group (P=0.007, P=0.002, respectively). Infiltration of Foxp3 Tregs was significantly associated with tumor invasion depth (P<0.001). The DC density was significantly correlated with histopathologic type (P=0.035), invasion depth (P=0.002), TNM stage (P=0.018), and lymph node metastasis (P<0.001). There was no significant difference of patient's OS between NACT and nNACT groups (P=0.452); however, patients treated with NACT had longer OS with lower infiltration of Foxp3 Tregs (P<0.001) and higher infiltration of DCs (P=0.010). Univariate and multivariate analyses indicated that infiltration of Foxp3 Tregs and DCs were independent prognostic factors (P=0.002, P=0.003, respectively). The results demonstrated that NACT could decrease intratumoral Foxp3 Tregs infiltration and increase DCs density, and that infiltration of Foxp3 Tregs and DCs may serve as novel prognostic biomarkers of human GC.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Chemotherapy, Adjuvant
Female
Fluorouracil therapeutic use
Forkhead Transcription Factors immunology
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Leucovorin therapeutic use
Lymphocytes, Tumor-Infiltrating immunology
Male
Middle Aged
Organoplatinum Compounds therapeutic use
Prognosis
Proportional Hazards Models
Stomach Neoplasms drug therapy
Stomach Neoplasms immunology
T-Lymphocytes, Regulatory immunology
Dendritic Cells drug effects
Lymphocytes, Tumor-Infiltrating drug effects
Neoadjuvant Therapy
Stomach Neoplasms pathology
T-Lymphocytes, Regulatory drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2625
- Volume :
- 7
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of clinical and experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 25197340