Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma.

Authors :: Brinkhuizen T
Reinders MG
van Geel M
Hendriksen AJ
Paulussen AD
Winnepenninckx VJ
Keymeulen KB
Soetekouw PM
van Steensel MA
Mosterd K
Source :: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2014 Nov; Vol. 71 (5), pp. 1005-8. Date of Electronic Publication: 2014 Sep 04.
Publication Year :: 2014

Subjects :: Aged
Carcinoma, Basal Cell drug therapy
DNA Mutational Analysis
Female
Humans
Skin Neoplasms drug therapy
Smoothened Receptor
Anilides therapeutic use
Antineoplastic Agents therapeutic use
Carcinoma, Basal Cell genetics
Drug Resistance, Neoplasm genetics
Neoplasm Recurrence, Local genetics
Pyridines therapeutic use
Receptors, G-Protein-Coupled genetics
Skin Neoplasms genetics

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