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[Bacterial ecology and resistance to antibiotics in patients with neurogenic overactive bladder treated with intravesical botulinum toxin injections].
- Source :
-
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie [Prog Urol] 2014 Oct; Vol. 24 (12), pp. 744-9. Date of Electronic Publication: 2014 Sep 06. - Publication Year :
- 2014
-
Abstract
- Introduction: For the last ten years, botulinum neurotoxin type A has become the gold standard for the treatment of neurogenic overactive detrusor. Bacterial colonization is common for these patients using clean intermittent self-catheterization, and toxin injections are at risk of urinary tract infections.<br />Objectives: The aim of our study was to determine the prevalence of different germs and their resistance to antibiotics in patients with neurogenic bladder, treated with intravesical botulinum toxin injections.<br />Material and Method: This epidemiologic study took place from September to October 2012 in a urodynamic and neurourology unit in a teaching hospital in Paris, France.<br />Results: Eighty patients with a valid urine culture according to our protocol, were included. Fourty-four culture were positive with 45 bacteria. We found an Escherichia coli in 42.5%, a Klebsiella pneumoniae in 7.5%, a Citrobacter freundii and an enterococcus in 2.5%, and a Staphylococcus aureus in 1.25%. Penicillin resistance were found in 51.11%, 3rd generation cephalosporins in 8.89%, quinolones in 28.89% and sulfamids in 24.44%. None were resistant to fosfomycin.<br />Conclusion: E. coli was the most frequent bacterium. No resistance to fosfomycin was found.<br /> (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Administration, Intravesical
Drug Resistance, Bacterial
Female
Humans
Male
Middle Aged
Prospective Studies
Botulinum Toxins, Type A administration & dosage
Neuromuscular Agents administration & dosage
Urinary Bladder microbiology
Urinary Bladder, Overactive drug therapy
Urinary Bladder, Overactive microbiology
Subjects
Details
- Language :
- French
- ISSN :
- 1166-7087
- Volume :
- 24
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
- Publication Type :
- Academic Journal
- Accession number :
- 25199730
- Full Text :
- https://doi.org/10.1016/j.purol.2014.07.016