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Association between cyclin D1 G870A polymorphism and cervical cancer risk: a cumulative meta-analysis involving 2,864 patients and 3,898 controls.
- Source :
-
Diagnostic pathology [Diagn Pathol] 2014 Sep 10; Vol. 9, pp. 168. Date of Electronic Publication: 2014 Sep 10. - Publication Year :
- 2014
-
Abstract
- Background: Association between Cyclin D1 (CCND1) polymorphism and cervical cancer risk are conflicting with published articles. We performed a meta-analysis to investigate the association between CCND1 G870A polymorphism and cervical cancer risk.<br />Methods: PubMed, Embase and CNKI data were researched to conduct a meta-analysis on the associations between CCND1 G870A polymorphism and cervical cancer risk. Ten published case-control studies including 2,864 patients with cervical cancer and 3,898 controls were collected in this meta-analysis. Odds ratio (OR) with 95% confidence interval (CI) were applied to assess the relationship; meta-regression, sensitivity analysis and cumulative analysis were also conducted to guarantee the strength of results.<br />Results: Overall, no significant association between CCND1 G870A polymorphism and cervical cancer risk were found in allele contrast (A vs. G: OR=1.02, 95% CI=0.88-1.19, P=0.76 I2=74.5%), codominant model (GA vs. GG: OR=0.98, 95% CI=0.77-1.26, P=0.90 I2=69.1%; AA vs GG: OR=1.03, 95% CI=0.75-1.41, P=0.85 I2=75.9%), dominant model (GA + AA vs. GG: OR=1.00, 95% CI=0.78-1.28, P=0.99 I2=72.3%) and recessive model (AA vs GG + GA: OR=1.06, 95% CI=0.85-1.23, P=0.62, I2=70.1%). Similarly, in the stratified analysis by ethnicity, study design and genotyping type, no significant association detected in all genetic models either.<br />Conclusions: Our meta-analysis indicated that CCND1 G870A might be not the crucial risk factor for the development of cervical cancer.<br />Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000&#95;2014&#95;168.
Details
- Language :
- English
- ISSN :
- 1746-1596
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Diagnostic pathology
- Publication Type :
- Academic Journal
- Accession number :
- 25204741
- Full Text :
- https://doi.org/10.1186/s13000-014-0168-x