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Circulating 25-hydroxyvitamin D3 in relation to renal cell carcinoma incidence and survival in the EPIC cohort.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 2014 Oct 15; Vol. 180 (8), pp. 810-20. Date of Electronic Publication: 2014 Sep 08. - Publication Year :
- 2014
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Abstract
- Normal renal function is essential for vitamin D metabolism, but it is unclear whether circulating vitamin D is associated with risk of renal cell carcinoma (RCC). We assessed whether 25-hydroxyvitamin D3 (25(OH)D3) was associated with risk of RCC and death after RCC diagnosis in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC recruited 385,747 participants with blood samples between 1992 and 2000. The current study included 560 RCC cases, 557 individually matched controls, and 553 additional controls. Circulating 25(OH)D3 was assessed by mass spectrometry. Conditional and unconditional logistic regression models were used to calculate odds ratios and 95% confidence intervals. Death after RCC diagnosis was assessed using Cox proportional hazards models and flexible parametric survival models. A doubling of 25(OH)D3 was associated with 28% lower odds of RCC after adjustment for season of and age at blood collection, sex, and country of recruitment (odds ratio = 0.72, 95% confidence interval: 0.60, 0.86; P = 0.0004). This estimate was attenuated somewhat after additional adjustment for smoking status at baseline, circulating cotinine, body mass index (weight (kg)/height (m)(2)), and alcohol intake (odds ratio = 0.82, 95% confidence interval: 0.68, 0.99; P = 0.038). There was also some indication that both low and high 25(OH)D3 levels were associated with higher risk of death from any cause among RCC cases.<br /> (© The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Age Factors
Aged
Alcohol Drinking epidemiology
Body Mass Index
Carcinoma, Renal Cell mortality
Female
Humans
Incidence
Logistic Models
Male
Middle Aged
Odds Ratio
Proportional Hazards Models
Prospective Studies
Risk Factors
Sex Factors
Smoking epidemiology
White People
Calcifediol blood
Carcinoma, Renal Cell blood
Carcinoma, Renal Cell epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-6256
- Volume :
- 180
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 25205830
- Full Text :
- https://doi.org/10.1093/aje/kwu204