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Complement modulation of T cell immune responses during homeostasis and disease.
- Source :
-
Journal of leukocyte biology [J Leukoc Biol] 2014 Nov; Vol. 96 (5), pp. 745-56. Date of Electronic Publication: 2014 Sep 10. - Publication Year :
- 2014
-
Abstract
- The complement system is an ancient and critical effector mechanism of the innate immune system as it senses, kills, and clears infectious and/or dangerous particles and alerts the immune system to the presence of the infection and/or danger. Interestingly, an increasing number of reports have demonstrated a clear role for complement in the adaptive immune system as well. Of note, a number of recent studies have identified previously unknown roles for complement proteins, receptors, and regulators in T cell function. Here, we will review recent data demonstrating the influence of complement proteins C1q, C3b/iC3b, C3a (and C3aR), and C5a (and C5aR) and complement regulators DAF (CD55) and CD46 (MCP) on T cell function during homeostasis and disease. Although new concepts are beginning to emerge in the field of complement regulation of T cell function, future experiments should focus on whether complement is interacting directly with the T cell or is having an indirect effect on T cell function via APCs, the cytokine milieu, or downstream complement activation products. Importantly, the identification of the pivotal molecular pathways in the human systems will be beneficial in the translation of concepts derived from model systems to therapeutic targeting for treatment of human disorders.<br /> (© 2014 Society for Leukocyte Biology.)
- Subjects :
- Animals
CD55 Antigens genetics
CD55 Antigens immunology
CD55 Antigens metabolism
Complement C1q genetics
Complement C1q immunology
Complement C1q metabolism
Complement C3 genetics
Complement C3 immunology
Complement C3 metabolism
Complement C5a genetics
Complement C5a immunology
Complement C5a metabolism
Complement System Proteins genetics
Complement System Proteins metabolism
Homeostasis genetics
Humans
Membrane Cofactor Protein genetics
Membrane Cofactor Protein immunology
Membrane Cofactor Protein metabolism
T-Lymphocytes metabolism
Complement System Proteins immunology
Homeostasis immunology
Immunomodulation
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1938-3673
- Volume :
- 96
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of leukocyte biology
- Publication Type :
- Academic Journal
- Accession number :
- 25210145
- Full Text :
- https://doi.org/10.1189/jlb.3MR0214-109R