Back to Search
Start Over
Anaemia in pregnancy is associated with advanced HIV disease.
- Source :
-
PloS one [PLoS One] 2014 Sep 15; Vol. 9 (9), pp. e106103. Date of Electronic Publication: 2014 Sep 15 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Background: Anaemia is a common clinical finding in HIV infected women and has been associated with advanced disease. The use of antiretroviral drugs such as Zidovudine (ZDV) either for prevention of mother to child transmission (MTCT) of HIV or used in combination with other antiretrovirals have been implicated in the development or increased severity of anaemia. We report the prevalence, type, severity and incidence of anaemia in a cohort of HIV infected women who initiated antiretroviral prophylaxis or treatment during pregnancy.<br />Methods and Materials: This is a retrospective cohort data analysis of 408 HIV infected pregnant women who participated in a breastfeeding intervention study (HPTN 046 Study, ClinicalTrials.gov NCT 00074412) in South Africa. Women initiated zidovudine prophylaxis for PMTCT or triple antiretroviral treatment in pregnancy according to the standard of care. Laboratory and clinical data in pregnancy, <72 hours and 2 weeks postdelivery were extracted from the main database and analysed.<br />Results: The mean Hb concentration was 10.6 g/dL at baseline and 262/408 (64.2%) women were diagnosed with anaemia (Hb<11 g/dL) in pregnancy, 48/146 (32.9%) subsequently developed anaemia intrapartum or postpartum and 89/310 (28.7%) of all cases of anaemia remained unresolved by 2 weeks postdelivery. In a univariate analysis, CD4 count and gravidity were significant risk factors for anaemia in pregnancy, RR 1.41; 1.23-1.61 (p<0.001) and 1.10; 1.01-1.18 (pā=ā0.02) respectively. After adjusting for antiretroviral regimen, age and gravidity in a multivariable analysis, only the CD4 count remains a significant risk factor for anaemia in pregnancy and postdelivery.<br />Conclusion: In conclusion, anaemia was most common among women in the advanced stage of HIV infection (CD4<200 cells/mm3). There was no evidence of an association between ZDV or triple ARVs and anaemia.
- Subjects :
- Anemia epidemiology
Anti-HIV Agents therapeutic use
CD4 Lymphocyte Count
Disease Progression
Female
HIV Infections drug therapy
Humans
Incidence
Multivariate Analysis
Pregnancy
Prevalence
Retrospective Studies
Risk Factors
South Africa
Urinary Tract Infections complications
Urinary Tract Infections epidemiology
Zidovudine therapeutic use
Anemia complications
Anti-HIV Agents adverse effects
HIV Infections complications
Pregnancy Complications, Hematologic epidemiology
Zidovudine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25222119
- Full Text :
- https://doi.org/10.1371/journal.pone.0106103