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A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2014 Sep 18; Vol. 15 (9), pp. 16484-99. Date of Electronic Publication: 2014 Sep 18. - Publication Year :
- 2014
-
Abstract
- Adolescent idiopathic scoliosis (AIS) is a common orthopedic disorder of unknown etiology and pathogenesis. Melatonin and melatonin pathway dysfunction has been widely suspected to play an important role in the pathogenesis. Many different types of animal models have been developed to induce experimental scoliosis mimicking the pathoanatomical features of idiopathic scoliosis in human. The scoliosis deformity was believed to be induced by pinealectomy and mediated through the resulting melatonin-deficiency. However, the lack of upright mechanical spinal loading and inherent rotational instability of the curvature render the similarity of these models to the human counterparts questionable. Different concerns have been raised challenging the scientific validity and limitations of each model. The objectives of this review follow the logical need to re-examine and compare the relevance and appropriateness of each of the animal models that have been used for studying the etiopathogenesis of adolescent idiopathic scoliosis in human in the past 15 to 20 years.
- Subjects :
- Adolescent
Animals
Chickens
Female
Haplorhini
Humans
Male
Melatonin physiology
Melatonin therapeutic use
Mice, Inbred Strains
Mice, Knockout
Phenotype
Pineal Gland metabolism
Posture
Rats, Sprague-Dawley
Rodentia
Rotation
Salmon
Scoliosis prevention & control
Signal Transduction
Species Specificity
Weight-Bearing
Disease Models, Animal
Melatonin deficiency
Pineal Gland surgery
Scoliosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 15
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25238413
- Full Text :
- https://doi.org/10.3390/ijms150916484