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Microfluidic platforms for the investigation of intercellular signalling mechanisms.
- Source :
-
Small (Weinheim an der Bergstrasse, Germany) [Small] 2014 Dec 10; Vol. 10 (23), pp. 4810-26. Date of Electronic Publication: 2014 Sep 19. - Publication Year :
- 2014
-
Abstract
- Intercellular signalling has been identified as a highly complex process, responsible for orchestrating many physiological functions. While conventional methods of investigation have been useful, their limitations are impeding further development. Microfluidics offers an opportunity to overcome some of these limitations. Most notably, microfluidic systems can emulate the in-vivo environments. Further, they enable exceptionally precise control of the microenvironment, allowing complex mechanisms to be selectively isolated and studied in detail. There has thus been a growing adoption of microfluidic platforms for investigation of cell signalling mechanisms. This review provides an overview of the different signalling mechanisms and discusses the methods used to study them, with a focus on the microfluidic devices developed for this purpose.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Coculture Techniques
Diffusion
Equipment Design
Gap Junctions metabolism
Green Fluorescent Proteins metabolism
HEK293 Cells
Hippocampus metabolism
Humans
Neurons metabolism
Synapses metabolism
Cell Communication
Microfluidic Analytical Techniques
Microfluidics methods
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1613-6829
- Volume :
- 10
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 25238429
- Full Text :
- https://doi.org/10.1002/smll.201401444