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[Local recurrence based on size after conservative surgery in breast cancer stage T1-T2. A population-based study].
- Source :
-
Cirugia y cirujanos [Cir Cir] 2014 May-Jun; Vol. 82 (3), pp. 252-61. - Publication Year :
- 2014
-
Abstract
- Background: Conservative surgery can be regarded as the standard treatment for most early stage breast tumors. However, a minority of patients treated with conservative surgery will present local or locoregional recurrence. Therefore, it is of interest to evaluate the possible factors associated with this recurrence.<br />Methods: A population-based retrospective study using data from the Tumor Registry of Castellón (Valencia, Spain) of patients operated on for primary nonmetastatic breast cancer between January 2000 and December 2008 was designed. Kaplan-Meier curves and log-rank test to estimate 5-year local recurrence were used. Two groups of patients were defined, one with conservative surgery and another with nonconservative surgery. Cox multivariate analysis was conducted.<br />Results: The total number of patients was 410. Average local recurrence was 6.8%. In univariate analysis, only tumor size and lymph node involvement showed significant differences. On multivariate analysis, independent prognostic factors were conservative surgery (hazard ratio [HR] 4.62; 95% confidence interval [CI]: 1.12-16.82), number of positive lymph nodes (HR 1.07; 95% CI: 1.01-1.17) and tumor size (in mm) (HR 1.02; 95% CI: 1.01-1.06).<br />Conclusions: Local recurrence after breast-conserving surgery is higher in tumors >2 cm. Although tumor size should not be a contraindication for conservative surgery, it should be a risk factor to be considered.
- Subjects :
- Aged
Aged, 80 and over
Breast Neoplasms epidemiology
Breast Neoplasms pathology
Breast Neoplasms therapy
Carcinoma epidemiology
Carcinoma pathology
Carcinoma therapy
Chemotherapy, Adjuvant
Combined Modality Therapy
Estrogens
Female
Genes, erbB-2
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Neoplasms, Hormone-Dependent epidemiology
Neoplasms, Hormone-Dependent pathology
Neoplasms, Hormone-Dependent surgery
Neoplasms, Hormone-Dependent therapy
Progesterone
Prognosis
Proportional Hazards Models
Radiotherapy, Adjuvant
Registries statistics & numerical data
Retrospective Studies
Spain epidemiology
Triple Negative Breast Neoplasms epidemiology
Triple Negative Breast Neoplasms pathology
Triple Negative Breast Neoplasms surgery
Triple Negative Breast Neoplasms therapy
Tumor Burden
Breast Neoplasms surgery
Carcinoma surgery
Mastectomy, Segmental methods
Neoplasm Recurrence, Local epidemiology
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 2444-054X
- Volume :
- 82
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cirugia y cirujanos
- Publication Type :
- Academic Journal
- Accession number :
- 25238466