Back to Search
Start Over
Is there an intermediate-risk non-seminoma? long-term treatment results from a single center.
- Source :
-
Journal of B.U.ON. : official journal of the Balkan Union of Oncology [J BUON] 2014 Jul-Sep; Vol. 19 (3), pp. 775-9. - Publication Year :
- 2014
-
Abstract
- Purpose: We retrospectively assessed the treatment results of patients with testicular non-seminoma to evaluate possible predictive and prognostic factors.<br />Methods: 189 patients with testicular non-seminoma treated between 2000 and 2012 were retrospectively evaluated. Treatment was based on orchiectomy plus chemotherapy (bleomycin/etoposide/cisplatin and vinblastine/ifosfamide/ cisplatin); retroperitoneal lymphadenectomy was only performed for residual disease after chemotherapy. The treatment protocol was updated regularly according to international standards. Overall survival (OS) was evaluated with the Kaplan-Meier method at a significance level of 5% according to stage, Karnofsky performance status (KPS), and chemotherapy dose intensity.<br />Results: OS differed significantly for patients at different TNM stages (p=0.000); however, detailed analysis revealed significantly worse survival only in stage IIIC (10-year OS for IIIC vs IIIA+B, 35 vs 88%, p=0.001), while the difference between IIIB and lower stages was not significant (p=0.383). Patients with no chemotherapy dose reduction had significantly higher OS than those with any kind of dose reduction (10-year OS 96 vs 0%, p=0.000). For stage IIIC disease, however, dose intensity had no influence on OS (p=0.167). KPS had no prognostic significance for OS (KPS<80 vs ≥80, p=0.627) for stage IIIA+B and for stage IIIC.<br />Conclusion: The standard of care for testicular non-seminoma offers excellent prognosis with no significant differences in OS for good- and intermediate-risk patients. Reduction of chemotherapy dose negatively impacted OS in patients with stage IIIA+B and thus should be avoided.
- Subjects :
- Adolescent
Adult
Aged
Combined Modality Therapy
Humans
Male
Middle Aged
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal mortality
Neoplasms, Germ Cell and Embryonal pathology
Retrospective Studies
Risk
Testicular Neoplasms mortality
Testicular Neoplasms pathology
Neoplasms, Germ Cell and Embryonal therapy
Testicular Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1107-0625
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of B.U.ON. : official journal of the Balkan Union of Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25261666