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Regulation of Fc epsilon receptor 2 (CD23) expression on a human eosinophilic cell line EoL3 and a human monocytic cell line U937 by transforming growth factor beta.
- Source :
-
Cellular immunology [Cell Immunol] 1989 Aug; Vol. 122 (1), pp. 96-107. - Publication Year :
- 1989
-
Abstract
- Regulation of low-affinity receptors for IgE (Fc epsilon R2/CD23) on a human eosinophilic cell line EoL3 and a human monocytic cell line U937 was studied using an anti-Fc,R2/CD23 monoclonal antibody H107 by flow cytometry. While platelet-activating factor, interleukin 4, and interferon gamma significantly augmented Fc epsilon R2/CD23 expression on both cell lines, transforming growth factor beta (TGF beta) inhibited both the basal level of Fc epsilon R2/CD23 expression and the enhanced Fc epsilon R2/CD23 expression induced by these reagents in dose- and time-dependent manners. However, TGF beta did not significantly suppress the high basal level of Fc epsilon R2/CD23 expression on RPMI 8866 cells. These results suggest that Fc epsilon R2/CD23 expression on EoL3 and U937 cells is regulated by various cytokines and growth factors, and that TGF beta plays an important regulatory role in IgE-mediated immune responses.
- Subjects :
- Cell Line, Transformed
Dexamethasone pharmacology
Humans
Interferon-gamma pharmacology
Interleukin-4
Interleukins pharmacology
Leukemia, Eosinophilic, Acute immunology
Leukemia, Myeloid immunology
Platelet Activating Factor pharmacology
Receptors, IgE
Antigens, Differentiation, B-Lymphocyte analysis
Eosinophils immunology
Monocytes immunology
Receptors, Fc analysis
Transforming Growth Factors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0008-8749
- Volume :
- 122
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cellular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 2526691
- Full Text :
- https://doi.org/10.1016/0008-8749(89)90151-2