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The relationship between antibeta 2 glycoprotein antibodies and SYNTAX score in patients undergoing coronary artery by-pass graft surgery.
- Source :
-
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2014; Vol. 18 (17), pp. 2556-61. - Publication Year :
- 2014
-
Abstract
- Objective: The SYNTAX Score was recently developed to characterize the coronary vasculature with respect to the number of lesion's location, complexity, and functional impact and it is a quantitative scoring system to assist with patient selection for optimal revascularization strategy between percutaneous coronary intervention (PCI) and coronary artery by-pass surgery (CABG). b2-glycoprotein I (b2GPI), a plasma protein that binds cardiolipin, acts as a modulator of platelet aggregation and coagulation. Antibodies to b2GPI may have a role in atherosclerosis by inducing endothelial cell activation. We investigated the relationship between anti beta 2 GPI and severity of coronary artery stenosis by calculating the SYNTAX Score among patients undergoing CABG surgery.<br />Patients and Methods: We prospectively investigate 612 patients who undergo elective coronary angiography between September 2012 and June 2013. Patients were evaluated for blood chemistry and anti-b2GPI IgA, IgM and IgG. Ninety seven patients with complete biochemical analysis including anti Beta 2 GPI antibodies and undergone CABG have been enrolled in this study. We divided patients in to 2 groups according to the SYNTAX scores. Group 1 included 48 patients with low SYNTAX scores (<23) and group 2 included 49 patients with intermediate and high SYNTAX scores (>23).<br />Results: There was significant correlation between elevated anti b2GPI IgG levels and higher SYNTAX score which indicate advanced and complex CAD. In this study, lesion complexity increased progressively with increasing anti-b2GPI-IgG type of antibody levels. According to this findings, anti-b2GPI-IgG is a strong predictor of higher SYNTAX score.<br />Conclusions: In addition to the traditional risk factors for atherosclerosis, the proinflammatory and procoagulant activities of antiphospholipid antibodies appear to be important risk factors for atherosclerotic occlusive disease.
- Subjects :
- Angioplasty, Balloon, Coronary
Atherosclerosis immunology
Atherosclerosis pathology
Coronary Artery Disease blood
Coronary Artery Disease pathology
Coronary Stenosis immunology
Coronary Stenosis pathology
Coronary Vessels pathology
Female
Humans
Immunoglobulin G immunology
Male
Middle Aged
Risk Factors
Severity of Illness Index
Coronary Artery Bypass methods
Coronary Artery Disease immunology
Coronary Artery Disease surgery
Immunoglobulin G blood
Risk Assessment methods
beta 2-Glycoprotein I immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2284-0729
- Volume :
- 18
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- European review for medical and pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25268105