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Enantioselective synthesis of 3-substituted 1,2-oxazinanes via organocatalytic intramolecular aza-Michael addition.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2014 Nov 21; Vol. 12 (43), pp. 8607-10. - Publication Year :
- 2014
-
Abstract
- A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er). These reactions were enabled by a quinine-derived primary-tertiary diamine as a catalyst and pentafluoropropionic acid (PFP) as a co-catalyst.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 12
- Issue :
- 43
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25272305
- Full Text :
- https://doi.org/10.1039/c4ob01646g