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Radical based strategy toward the synthesis of 2,3-dihydrofurans from aryl ketones and aromatic olefins.
- Source :
-
Organic letters [Org Lett] 2014 Oct 17; Vol. 16 (20), pp. 5446-9. Date of Electronic Publication: 2014 Oct 02. - Publication Year :
- 2014
-
Abstract
- A copper-mediated annulation of aryl ketones with a wide range of aromatic olefins has been developed. This strategy allowed convenient access to 2,3-dihydrofuran derivatives. The versatility of the protocol is shown by synthesizing α-methyl dihydrofurans, which serve as an intermediate for the synthesis of vitamin B1. In addition, the applicability of the protocol in conjugated systems is demonstrated. A radical pathway was presumed and supported for annulation of aryl ketones with olefins.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 25275799
- Full Text :
- https://doi.org/10.1021/ol502688r