Back to Search
Start Over
Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties.
- Source :
-
International journal of hygiene and environmental health [Int J Hyg Environ Health] 2015 Jan; Vol. 218 (1), pp. 91-8. Date of Electronic Publication: 2014 Sep 06. - Publication Year :
- 2015
-
Abstract
- The aim was to characterize placental transfer of some congeners of polychlorinated biphenyls (PCBs) and to relate human in utero exposure to these pollutants to their physicochemical properties. We included into the study 1134 births during the period 2002-2003 from two highly PCB contaminated districts in eastern Slovakia. Concentrations of 15 PCB congeners (IUPAC No. 28, 52, 101, 123(+149), 118, 114, 153, 105, 138(+163), 167, 156(+171), 157, 180, 170, and 189) in umbilical cord (C) and maternal serum (M) were determined. The C/M ratios were significantly related, either positively or inversely depending on parameter, to the logarithm of partition coefficient octanol-water (KOW), to fusion enthalpy at the melting point, molecular weight, water solubility, total surface area of the molecule, solvent accessible surface area, melting point, molar volume, and molecular electronegativity distance vector. We found an inverse association between logKOW and lipid adjusted logC/M (const=1.078, b1=-0.179, p<0.001, R(2)=0.039). Parameters evaluated were interrelated except fusion enthalpy at the melting point and electron affinity vs. solubility. We discuss the possible role of cholesterol as a transplacental transporter of PCBs.<br /> (Copyright © 2014 Elsevier GmbH. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1618-131X
- Volume :
- 218
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of hygiene and environmental health
- Publication Type :
- Academic Journal
- Accession number :
- 25277764
- Full Text :
- https://doi.org/10.1016/j.ijheh.2014.08.003